{"id":20,"date":"2025-02-12T15:12:51","date_gmt":"2025-02-12T15:12:51","guid":{"rendered":"http:\/\/www.vampire-eu.com\/home\/"},"modified":"2025-06-17T15:57:30","modified_gmt":"2025-06-17T15:57:30","slug":"home-2","status":"publish","type":"page","link":"https:\/\/www.vampire-eu.com\/pl\/","title":{"rendered":"Strona g\u0142\u00f3wna"},"content":{"rendered":"
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V\u03b1MPiRE
Walidacja modyfikacji alfa-synukleiny w ewolucji choroby Parkinsona<\/h2><\/div><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n
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V\u03b1MPiRE w skr\u00f3cie<\/h2><\/div>

Choroba Parkinsona (PD) to post\u0119puj\u0105ce schorzenie neurodegeneracyjne, kt\u00f3re dotyka ponad 9,4 miliona os\u00f3b na ca\u0142ym \u015bwiecie, a do 2040 roku liczba przypadk\u00f3w mo\u017ce przekroczy\u0107 12 milion\u00f3w. Pomimo post\u0119p\u00f3w, wczesna diagnoza i leczenie pozostaj\u0105 trudne z powodu braku wiarygodnych biomarker\u00f3w. Nieprawid\u0142owo uformowane bia\u0142ka \u03b1-synukleiny odgrywaj\u0105 kluczow\u0105 rol\u0119 w patogenezie PD i sta\u0142y si\u0119 obiecuj\u0105cymi celami diagnostycznymi. Finansowany przez UE projekt V\u03b1MPiRE zbada izoformy \u03b1-synukleiny w neuronowo pochodnych p\u0119cherzykach zewn\u0105trzkom\u00f3rkowych pochodz\u0105cych z du\u017cej kohorty pacjent\u00f3w z PD i os\u00f3b bez PD. Wyniki projektu przyczyni\u0105 si\u0119 do opracowania nowego testu diagnostycznego in vitro (IVD) do wczesnego wykrywania PD i monitorowania jej post\u0119pu. To innowacyjne rozwi\u0105zanie mo\u017ce usprawni\u0107 wczesne badania przesiewowe i wykrywanie choroby, poprawi\u0107 zarz\u0105dzanie leczeniem i wyniki pacjent\u00f3w oraz doprowadzi\u0107 do opracowania lepszych terapii.<\/p><\/div><\/div><\/div>\n\n\n\n

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Ulepszone badania przesiewowe w kierunku choroby Parkinsona umo\u017cliwi\u0105 wcze\u015bniejsze wykrycie 270.000 nowych przypadk\u00f3w rocznie oraz lepsze zarz\u0105dzanie chorob\u0105 u 9,4 miliona obecnie zdiagnozowanych os\u00f3b. Pozwoli to unikn\u0105\u0107 utraty 5,8 miliona lat \u017cycia skorygowanych o niepe\u0142nosprawno\u015b\u0107 (DALY) do 2028 roku i u\u0142atwi rozw\u00f3j skuteczniejszych terapii.<\/em><\/em><\/em><\/em><\/em><\/p><\/div><\/div><\/div>\n\n\n\n

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Rekrutujemy uczestnik\u00f3w do naszego badania klinicznego!<\/a><\/strong><\/h3><\/div>

Niezale\u017cnie od tego, czy masz chorob\u0119 Parkinsona, czy nie, mo\u017cesz pom\u00f3c nam w rozwijaniu wczesnego wykrywania tej choroby<\/a><\/p><\/div><\/div><\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

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Prze\u0142om w walce z chorob\u0105 Parkinsona<\/h2><\/div><\/div><\/div>\n\n\n\n
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Choroba Parkinsona (PD) stanowi wyzwanie dla milion\u00f3w ludzi na ca\u0142ym \u015bwiecie \u2013 jej post\u0119puj\u0105cy charakter zmusza pacjent\u00f3w i opiekun\u00f3w do nieustannej walki z jej wyniszczaj\u0105cymi skutkami. Pomimo lat bada\u0144, brak wczesnych narz\u0119dzi diagnostycznych i skutecznych biomarker\u00f3w sprawia\u0142, \u017ce byli\u015bmy o krok za chorob\u0105. Teraz jednak V\u03b1MPiRE, nasza prze\u0142omowa inicjatywa, ma szans\u0119 odmieni\u0107 ten obraz.

Ten wizjonerski projekt ma na celu zrewolucjonizowanie wczesnego wykrywania, rokowania i leczenia choroby Parkinsona dzi\u0119ki nowoczesnej nauce i innowacjom.<\/p><\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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Nowe spojrzenie na wczesne wykrywanie<\/strong><\/h3><\/div>

Wykorzystuj\u0105c najnowsze odkrycia, przeanalizujemy izoformy i biomarkery \u03b1-synukleiny (\u03b1-Syn) w neuronowo pochodnych p\u0119cherzykach zewn\u0105trzkom\u00f3rkowych (NDEV), korzystaj\u0105c z pr\u00f3bek krwi od 1\u202f200 uczestnik\u00f3w. Nasze podej\u015bcie ma na celu wykrycie najwcze\u015bniejszych sygna\u0142\u00f3w choroby Parkinsona.<\/p><\/div><\/div><\/div>\n\n\n\n

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Spostrze\u017cenia wspierane przez AI<\/strong><\/h3><\/div>

Wykorzystuj\u0105c zaawansowane algorytmy AI, przekszta\u0142cimy z\u0142o\u017cone dane biomarker\u00f3w w praktyczne narz\u0119dzia diagnostyczne, zapewniaj\u0105c precyzj\u0119 i niezawodno\u015b\u0107 w rzeczywistych warunkach klinicznych.<\/p><\/div><\/div><\/div>\n\n\n\n

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Wsp\u00f3lne przedsi\u0119wzi\u0119cie<\/strong><\/h3><\/div>

Wsp\u00f3\u0142pracuj\u0105c z czo\u0142owymi laboratoriami i producentami test\u00f3w diagnostycznych in vitro, d\u0105\u017cymy do stworzenia i walidacji innowacyjnego testu diagnostycznego in vitro. Prototyp ten pozwoli na wczesne wykrycie choroby Parkinsona, oszacowanie post\u0119pu choroby oraz monitorowanie odpowiedzi na leczenie.<\/p><\/div><\/div><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

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Do\u0142\u0105cz do nas w tej prze\u0142omowej podr\u00f3\u017cy<\/h2><\/div>

V\u03b1MPiRE to co\u015b wi\u0119cej ni\u017c projekt; to ruch na rzecz zmiany sposobu walki z chorob\u0105 Parkinsona. Kszta\u0142tujmy razem przysz\u0142o\u015b\u0107, toruj\u0105c drog\u0119 do wcze\u015bniejszych interwencji, lepszych terapii i nadziei dla milion\u00f3w.<\/p><\/div><\/div>\n<\/div>\n\n\n\n

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Rewolucjonizowanie wczesnego wykrywania i prognozowania choroby Parkinsona<\/strong><\/h3><\/div>

Dzi\u0119ki rygorystycznym badaniom, comiesi\u0119cznym kontrolom i nowoczesnym metodom walidacji, V\u03b1MPiRE zapewni wczesne wykrywanie Parkinsona oraz prognozowanie przebiegu i wynik\u00f3w leczenia.
Badanie pod\u0142u\u017cne obejmuje 24-miesi\u0119czn\u0105 obserwacj\u0119 zar\u00f3wno uczestnik\u00f3w z chorob\u0105 Parkinsona, jak i bez niej, zrekrutowanych zgodnie z metodologi\u0105 badania klinicznego typu case-control uwzgl\u0119dniaj\u0105c\u0105 grupowanie.
W tym okresie obie kohorty b\u0119d\u0105 monitorowane za pomoc\u0105 comiesi\u0119cznych ankiet post\u0119pu. Pozwoli to na weryfikacj\u0119 nie tylko mocy statystycznej wykrywania choroby Parkinsona, ale tak\u017ce post\u0119pu choroby i reakcji na leczenie.
Oczekuje si\u0119 r\u00f3wnie\u017c, \u017ce oko\u0142o 5% os\u00f3b pocz\u0105tkowo zrekrutowanych jako niechoruj\u0105ce na Parkinsona rozwinie chorob\u0119. Umo\u017cliwi to ustalenie zdolno\u015bci wykrywania we wczesnych stadiach.<\/p><\/div><\/div><\/div>\n\n\n\n

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Przekszta\u0142canie diagnozy choroby Parkinsona: dost\u0119pna, przyst\u0119pna i skuteczna<\/strong><\/h3><\/div>

Wyobra\u017camy sobie przysz\u0142o\u015b\u0107, w kt\u00f3rej wczesna diagnoza choroby Parkinsona b\u0119dzie dost\u0119pna, przyst\u0119pna i prze\u0142omowa. Nasz konsorcjum zobowi\u0105zuje si\u0119 przeku\u0107 te odkrycia w skomercjalizowane rozwi\u0105zania, kt\u00f3re przynios\u0105 korzy\u015bci pacjentom i systemom opieki zdrowotnej na ca\u0142ym \u015bwiecie.<\/p><\/div><\/div><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

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Projekt otrzyma\u0142 dofinansowanie z programu Unii Europejskiej HORIZON-HLTH-2024-DISEASE-03-two-stage. grant agreement No 101156370<\/a>.
Przedstawione pogl\u0105dy i opinie s\u0105 wy\u0142\u0105cznie autorstwa autora(-\u00f3w) i niekoniecznie odzwierciedlaj\u0105 stanowisko Unii Europejskiej ani programu HORIZON-RIA. Unia Europejska ani organ przyznaj\u0105cy \u015brodki nie ponosz\u0105 za nie odpowiedzialno\u015bci.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"enabled","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-20","page","type-page","status-publish","hentry"],"yoast_head":"\nHome - 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