{"id":5134,"date":"2025-05-07T12:07:30","date_gmt":"2025-05-07T12:07:30","guid":{"rendered":"https:\/\/www.vampire-eu.com\/?p=5134"},"modified":"2025-12-09T10:30:34","modified_gmt":"2025-12-09T10:30:34","slug":"harnessing-neuronal-biomarkers-in-blood-for-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/www.vampire-eu.com\/el\/harnessing-neuronal-biomarkers-in-blood-for-parkinsons-disease\/","title":{"rendered":"Harnessing neuronal biomarkers in blood for Parkinson’s disease"},"content":{"rendered":"

Michelle M. Barnett 1,2<\/sup>, William R. Reay 3<\/sup>, Michael P. Geaghan 4<\/sup>, Dylan J. Kiltschewskij 1,2<\/sup>, Melissa J. Green 5,6<\/sup>, Judith Weidenhofer 1<\/sup>, Stephen J. Glatt 7<\/sup>, Murray J. Cairns 1,2*<\/sup><\/p>\n\n\n\n

1 <\/sup>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia 2 <\/sup>Precision Medicine Research Program, Hunter Medical Research Institute, Newcastle, NSW 2305, Australia 5<\/sup> Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia 4<\/sup> Kinghorn Centre for Clinical Genomics, Garvan Medical Research Institute, Darlinghurst, NSW 2010, Australia 5<\/sup> Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia 6<\/sup> Neuroscience Research Australia, Sydney, NSW, Australia 7<\/sup>Psychiatric Genetic Epidemiology and Neurobiology Laboratory (PsychGENe lab), Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York, USA<\/p>\n\n\n\n

Until recently, people with neurological disorders have not benefited from readily accessible biomarkers to diagnose and treat their illness. This may change now; a new technique, developed by the University of Newcastle in Australia, has demonstrated neuronal origin molecular changes from people living with psychiatric illness. This work was published in\u00a0Science Advances<\/em>\u00a0as “miRNA cargo in circulating vesicles from neurons is altered in individuals with schizophrenia and associated with severe disease<\/a>“.<\/p>\n\n\n\n

As described in the paper, blood samples were obtained from almost 500 individuals and processed to isolate neuron-derived extracellular vesicles (NDEVs). The encapsulated content of NDEVs represent their tissue of origin, thereby providing a portal to the brain. The analysis demonstrated that molecular signatures of synaptic dysfunction have profound implications for patients; from diagnosis to treatment guidance and precision medicine applications. <\/p>\n\n\n\n

This technique for non-invasively acquiring molecular signatures of neuronal health will now be leveraged to improve the lives of people with Parkinson’s disease through early detection and monitoring.<\/p>\n\n\n\n